Now: Julia Louis- Dreyfus
Julia Louis-Dreyfus seems like an unstoppable force. Before she made her comeback in 2011, she also appeared in The New Adventures of Old Christine. Did you know that the actress holds the record for the most Primetime Emmy wins of any lead female actress? Wow.

Now: Julia Louis Dreyfus
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Then: Gillian Anderson
Gillian Anderson dominated the late-night slot when she was cast in the role of Special Agent Scully on the hit show The X-Files. It was a character made in heaven for the independent actress who played the same character on the small screen for an impressive ten years.

Then: Gillian Anderson